The Gunners reached the final of the Carabao Cup last term, losing out to a Nico O’Reilly double at Wembley.
Under Mikel Arteta, Arsenal have treated England’s secondary cup competition very seriously - reaching the final once and making the semi-finals on two occasions.
Fleetwood Town entered the Carabao Cup at the first round stage, beating divisional rivals Chesterfield 1-0 at home. They cruised past another League Two side, Shrewsbury, 4-0 before claiming a Championship scalp with a 1-0 victory over Sheffield United in the previous round.
It is the first time Fleetwood have reached the last 16 of the competition and the Cod Army sit 18th in the fourth tier after 13 games.
Arteta’s Gunners entered the competition in the previous round, defeating Premier League rivals Ipswich Town 4-2 away from home.
Arsenal and Fleetwood have never faced each other in a competitive game before, but can the hosts make even more history by beating the Premier League champions?
Here’s everything you need to know about where to watch the match...
How to watch Fleetwood vs Arsenal
TV channel: In the UK, the game will be televised live on Sky Sports. Coverage starts at 7.30pm GMT on Sky Sports Main Event ahead of kick-off at 8pm.
Live stream: Sky Sports subscribers can also catch the contest live online via the Sky Go app and website.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog.