Rodrigo Mora and Matias Soulé are expected to start for Roma in a home game against Cagliari, but Paulo Dybala will likely go to the bench.
It kicks off at 20:45 CET [19:45 GMT] at the Stadio Olimpico in Rome.
The Giallorossi are without Manu Koné, Mile Svilar and Lorenzo Pellegrini, but Dybala is expected to return to the squad after recovering from a minor muscle injury.
Sky Sport and Gazzetta are among the Italian sources reporting that Mora and Soulé will start as attacking midfielders behind the sole striker, Malen.
The backline will rotate, with Mario Hermoso and Gianluca Mancini expected to be rested, making room for Leonardo Balerdi and Daniele Ghilardi.
Cagliari are without Harry Winks, Mattia Felici and Riyad Idrissi. Yukinari Sugawara could start for the first time in Serie A, pushing Ze Pedro to the bench.
Paul Mendy is favourite over Kevin Carlos, with Daniel Maldini starting as an attacking midfielder.
Roma vs. Cagliari – where to watch on TV
DAZN will broadcast the match live in the UK and Ireland, and Paramount+ in the USA. Football Italia will provide live updates via a live blog.
Roma vs. Cagliari – probable line-ups
Roma (3-4-2-1): Gollini; Ghilardi, Ndicka, Balerdi; Lulli, Cristante, Pisilli, Molina; Soulé, Mora; Malen.
Cagliari (4-3-2-1): Caprile; Sugawara, Mina, Rodriguez, Obert; Romano, Deiola; Adopo, Maldini, Fazzini; Mendy.